子宫血管生物学

ResearchFocus：ResearchintheUterineVascularBiologyLaboratoryfocuseson4mainthemes。1、RegulatorsoftrophoblastinvasionInvasionofthematernaldeciduaandinnerthirdofmyometriumbyextravilloustrophoblastcellsandthesubsequentremodelingoftheuterinespiralarteriesisoneofthekeyeventsinearlypregnancy;failuresintheseprocessesbeingassociatedwithmajorcomplicationsofpregnancy。Ourresearchaimstoidentifysomeofthekeyregulatorymechanismsintheseprocesseswiththeultimateaimtodevelopearlyinterventionsforpreventionofthesepregnancycomplications。2、RegulatorsofVSMC（de）differentiationVascularsmoothmusclecellscanswitchfromasynthetictocontractilephenotypeandviceversadependingonthemicroenvironment。TheswitchfromcontractivetosyntheticisakeyfeatureofspiralarteryremodelingandwehaveidentifiedAng2andvitaminDasoneofthekeymediatorsofthisprocess。Ourresearchaimstounderstandthemolecularbasisofthisphenotypicswitchingandhowitcanbeutilizedtherapeutically。3、Regulatorsofendometriummaturationinhealthanddisease（recurrentmiscarriage，heavymenstrualbleeding，endometriosis）Aberrantendometrialmaturationisafeatureofrecurrentmiscarriage（advanced）andheavymenstrualbleeding（halted）associatedwithTGF-β1signalling。Currentresearchisfocusedonunderstandingthecompletemolecularbasisofthistodeveloptherapeuticsfortheseimportantgynecologyconditions。4、Regulatorsoftumorangiogenesis，metastasisandprogression（breast，endometrialandovarian）Poorprognosisformanytypesoftumorsisassociatedwithtumorangiogenesisandcancercellmetastasis。Manyofthesamepathwaysbeinginvestigatedinthetightlyregulatedprocessoftrophoblastinvasion/spiralarteryremodelingarealsorelevanttotumorangiogenesisandmetastasiswheretheyoccurinanuncontrolledmanner。Thereforewecanlearnaboutbothsystemsbydrawingparallelsbetweenthem。ResearchPersonnel：•SeniorscientistoDrQiYifeioDrZhaoMingguangoDrNingFenoDrChenMiaojuan•Post-doctoralfellowsoDrLuQinshengoDrWangQiong（secondarytutorwithDrShiKun）oDrDuanYaoyuan•TechniciansoMissWuPeihuangoMissDanWeioMrSunDingqian•MastersstudentsoMissHouHuomeioMissZhangMinoMissPanYue•Pastpost-doctoraltraineesoDrZhangJoyYueInternationalcollaborations：ProfessorsMarkKilbyandMartinHewison（UniversityofBirmingham，UK）–VitaminDandearlypregnancyDrAnnetteMeeson（NewcastleUniversity，UK）–CancerstemcellsandangiogenesisProfessorJanErnerudh（UniversityofLinkoping，Sweden）–RegulationofimmunecellsinearlypregnancyResearchGrantsAwarded：2018-2022Angiopoietin-2inducesvascularsmoothmusclecelldedifferentiationafterbindingtointegrinsubunits。NSFCProjectGrant580，000RMB。LashGE（PI）2017-2020IsendometrialgrowthandmaturationdependentonTGF-β1？NSFCProjectGrant570，000RMB。LashGE（PI）2017-2020TheroleofvitaminDdeficiencyintheaetiologyoflowbirthweightpregnancies。GuangzhouMunicipalGrant（collaborationwithUniversityofBirmingham）2，000，000RMB。LashGE（PI），QiuX，KilbyMD，HewisonM国家自然科学基金青年年项目，C080904，Noda1疫茴刈恶性黑色素瘤的防治作用及机制研究，2017/1-2019/12，20万元，在研，参加国家自然科学基金青年科学基金项目，项目编号：81702567，HE4通过Smad信号通路对子宫内膜癌细胞周期的调控机制研究，2018/01-2020/12，20万，在研，参加ResearchAwardsandFellowships：2016GuangzhouMedicalKeyTalent2016VisitingScholar，CollegeofVeterinaryMedicine，MichiganStateUniversity，Michigan，USASelectedrecentpublications：BulmerJN，LashGE（2019）Uterinenaturalkillercells：Timeforare-appraisal？F1000Res8。Pii：F1000FacultyRev-999。NingF，HouH，MorseAN，LashGE。（2019）Understandingandmanagementofgestationaltrophoblasticdisease。F1000Res。8。pii：F1000FacultyRev-428。WangJ，ZhangJY，WeiR，HuS，LinT，LashGE，TanM（2019）Serum25hydroxyvitaminDstatus，vitaminDsupplementationandfeedingpatternsin6-month-oldinfantsinGuangzhou，China：apairedlongitudinalfollowupstudy。MaternalandChildNutritionAccepted（IF：3.233）OtunHA，InnesBA，LashGE，SchiesslB，BallE，SearleRF，RobsonSC，BulmerJN（2019）QuantificationofspiralarteryremodellinginhumanplacentalbedusinganAdobePhotoshopbasedimageanalysistechnique。ReproductionInpress（IF：3.450）LuQ，HuangY，WuJ，GuanY，DuM，WangF，LiuZ，ZhuY，GongG，HouH，ZhangM，ZhangJY，NingF，ZhouQ，ChenL，WangL，LashGE（2019）T-cadherininhibitedinvasionandmigrationofendometrialstromalcellsinendometriosis。HumanReproductionInpress（IF：5.505）ManningR，JamesCP，SmithMC，InnesBA，StampE，PeeblesD，Baja-ElliottM，KleinN，BulmerJN，RobsonSC，LashGE（2019）Predictivevalueofcervicalcytokine，antimicrobialandmicrofloralevelsforpre-termbirthinhigh-riskwomen。ScientificReports9：11246。（IF：4.122）LiL，QiuX，LashGE，YuanL，LiangZ，LiuL。（2019）EffectofhormonereplacementtherapyonbonemineraldensityandbodycompositioninChineseadolescentandyoungadultTurnersyndromepatients。FrontiersinEndocrinology10：377（IF：3.519）RobsonA，LashGE，InnesBA，RobsonSC，BulmerJN（2019）Uterinenaturalkillercellsmediatededifferentiationofspiralarteryvascularsmoothmusclecellsinearlyhumanpregnancy。HumanReproduction34：1428-1438（IF：5.505）ZhangJY，WangJ，HuS，ChenD，LuQ，WeiR，TanM，LashGE（2019）CordserumvitaminDlevelsinaSouthChinabirthcohort。AsianPacificJournalofClinicalNutrition28：544-549。（IF：1.335）OldershawR，OwensA，SutherlandR，LinneyM，LiddleR，MaganaL，LashGE，GillJH，RichardsonG，MeesonA（2019）Humancardiacmesenchymalstemcelllikecells，anovelcellpopulationwiththerapeuticpotential。StemCellsandDevelopment28：593-607。（IF：3.315）LiL，LiQ，WangQ，LiuL，LiR，LiuH，HeY，LashGE（2019）RarecopynumbervariantsinthegenomeofChinesefemalechildrenandadolescentswithTurnersyndrome。BioscienceReports39：pii：BSR20181305。（IF：2.899）JiangM，LashGE，ZhaoX，LongY，GuoC，YangH（2018）CircRNA-0004904，CircRNA-0001855，andPAPP-A：Potentialnovelbiomarkersforthepredictionofpreeclampsia。CellularPhysiologyandBiochemistry46：2576-2586。（IF：5.5）ShiK，WangQ，SuY，XuanX，LiuY，ChenW，QianY，LashGE（2018）Identificationandfunctionalanalysesofdifferentiallyexpressedmetabolitesinearlystageendometrialcarcinoma。CancerScience109：1032-1043。（IF：4.372）BiswasShivhareS，BulmerJN，InnesBA，HapangamaDK，LashGE（2018）Endometrialvasculardevelopmentinmenorrhagia：alteredspatio-temporalpatternofexpressionofendothelialcellmarkersandextracellularmatrixcomponents。HumanReproduction33：399-410。（IF：5.505）LindauR，MehtaRB，LashGE，PapapavlouG，BoijR，BergG，JenmalmMC，ErnerudhJ，Svensson-ArvelundJ（2018）Interleukin-34ispresentatthefetal–maternalinterfaceandinducesimmunoregulatorymacrophagesofadecidualphenotypeinvitro。HumanReproduction33：588-599。（IF：5.505）WangQ，LashGE（2017）Angiopoietin2inplacentationandtumorbiology：theyinandyangofvascularbiology。Placenta。56：73-78。（IF：2.434）LiuZC，NingF，WangHF，ChenDY，CaiYN，ShengHY，LashGE，LiuL，DuJ。（2017）EpidermalgrowthfactorandtumornecrosisfactorαcooperativelypromotethemotilityofhepatocellularcarcinomacelllinesviasynergisticinductionoffibronectinbyNF-κB/p65。BiochimBiophysActa。1861：2568-2582。（IF：3.679）NingF，LiuH，LashGE（2016）Theroleofdecidualmacrophagesduringnormalandpathologicalpregnancy。AmJReprodImmunol。75：298-309。（IF：2.745）LairdSM，LashGE，LiTC，BulmerJN（2016）Theroleofnaturalkillercellsinhumanfertility。ScientificImpactPaperNo。53。RoyalCollegeofObstetricsandGynecology。https：//www.rcog.org.uk/en/guidelines-research-services/guidelines/the-role-of-natural-killer-cells-in-human-fertility-scientific-impact-paper-no。-53/ShiK，LiuL，HeYJ，YLX，LashGE，LiL（2016）BodycompositionandbonemineralstatusinpatientswithTurnersyndrome。ScientificReports6：38026。（IF：4.122）LashGE，BulmerJN，LiTC，InnesBA，MarieeN，PatelG，SandersonJ，QuenbyS，LairdSM（2016）Standardisationofuterinenaturalkiller（uNK）cellmeasurementsintheendometriumofwomenwithrecurrentreproductivefailure。JReprodImmunol116：50-59。（IF：2.232）LashGE，PitmanH，MorganHL，InnesBA，AgwuCN，BulmerJN（2016）Macrophages：keyregulatorsofvascularremodellinginhumanpregnancy。JLeukocBiol100：315-325。（IF：4.224）BiswasShivhareS，BulmerJN，InnesBA，HapangamaDK，LashGE（2015）Menstrualcycledistributionofuterinenaturalkillercellsisalteredinmenorrhagia。JReprodImmunol112：88-94。（IF：2.232）LantangAM，InnesBA，GanEH，PearceSH，LashGE（2015）Expressionofmelanocortinreceptorsinhumanendometrium。HumReprod30：2404-10。（IF：5.505）Svensson-ArvelundJ，MehtaRB，LindauR，MirrasekhianE，Rodriguez-MartinezH，BergG，LashGE，JenmalmMC，ErnerudhJ（2015）TheHumanFetalPlacentaPromotesToleranceagainsttheSemiallogeneicFetusbyInducingRegulatoryTCellsandHomeostaticM2Macrophages。JImmunol194：1534-44。（IF：4.539）